Cutting-edge innovation for improved drug delivery of active ingredients
HarmonyFilm™ delivers improved solubility, bioavailability, and ease of use for a better consumer experience
HarmonyFilm™ is our orally dissolvable film technology platform for optimizing the bioavailability and metabolism of therapeutic active ingredients. Orally dissolvable film technology is a versatile dose form for creating custom products with optimal release profiles.
HarmonyFilm™ products are about the size of a stamp, and can deliver therapeutic actives through the oral mucosal tissue sublingually or buccally. Oral transmucosal drug delivery is a non-invasive route that allows for the active ingredients to be absorbed directly into the vascularized tissue in the mouth, bypassing the hepatic first pass effect. This leads to reduced drug exposure and can offer a rapid onset of action.
Active ingredients in the HarmonyFilm™ can be either water-soluble or encapsulated for more effective absorption and sustained release. As oral dissolvable films dissolve quickly, no water is required for their consumption, improving user compliance – especially among children, and in conditions where users have difficulty in swallowing.
What actives are most suitable for sublingual / oral thin films
Oral thin films work best when the active is low-dose. The active ingredients in films are often incorporated as solid dispersions / nanosuspensions / micronized powders and are typically ~5–30% w/w of the film matrix.
Best-fit categories:
High-potency micronutrients (micro- to low-mg)
Examples: vitamin B12, folate, biotin, vitamin D3 / K2, iodine / selenium (trace minerals).
Typical workable dose:
~0.05–5 mg (sometimes up to ~10 mg).
Fast-onset “functional” actives that are effective at low doses
Examples: melatonin, caffeine micro-doses, certain nootropic alkaloids / extract actives.
Typical workable dose: ~1–50 mg.
Botanical / standardized extracts that are potent per mg
Examples: high-potency standardized extracts.
Typical workable dose: ~10 – 75 mg (higher loads often make films gritty and bitter).
Lipophilic actives
Examples: certain terpenes, fat-soluble vitamins, CoQ10-type actives with solubilization (emulsified / complexed) to avoid crystallization.
Typical workable dose:
usually low mg to tens of mg.
Peptides / fragile actives
Feasible when low dosage and protected / encapsulated.
Typical workable dose: micrograms to low mg.
Poor-fit categories (usually not viable in films)
High-dose minerals (Mg, Ca, K) and “gram-dose” amino acids.
Bulky botanicals that need 300–1000 mg per dose.
Strongly bitter / irritant actives.
What actives are most suitable for sublingual / oral thin films
Oral thin films work best when the active is low-dose. The active ingredients in films are often incorporated as solid dispersions / nanosuspensions / micronized powders and are typically ~5–30% w/w of the film matrix.
Our custom system delivers:
- Dual-Formulation
- Precision-Engineered Drying
- Guaranteed Dosage Accuracy
- Film Integrity
HarmonyFilm Sublingual ODF Film Benefits
- No unpleasant aftertaste, unlike pills
- Direct absorption into bloodstream
- No need for water or swallowing
- Precise dosing + faster onset
- Discreet
- Available in any flavor
- Multiple actives up to 150mg
- No need for water, swallowing, or chewing
- Multiples actives can be loaded onto one film
- Potential for reduced side effects with a lower dose